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Background: Hyperlipidemia (HL) constitutes a significant risk factor for cardiovascular diseases. This lipid disorder has become a primary focus for researchers because of its high prevalence worldwide, prompting increased efforts to discover new treatment options originating from natural alternatives to synthetic medications that can have serious adverse effects. Ethnopharmacological and ethnobotanical approaches have played a key role in documenting and identifying medicinal and aromatic plants. This survey aims to document Algerian medicinal plants (MPs) reported by local populations in the Ghardaïa region (Southern Algeria) as effective for the management of HL.